Discover cbg-ethz/scdna-pipe Open Source project

NGS-pipe: next-generation sequencing pipelines for precision oncology

130

NGS-pipe

Repo for the software suite ShoRAH (Short Reads Assembly into Haplotypes)

104

shorah

Mutual information estimators and benchmark

bmi

Viral quasispecies assembly via maximal clique finding. A method to reconstruct viral haplotypes and detect large insertions and deletions from NGS data.

haploclique

SCIPhI

Benchmarking data sets for haplotype reconstruction methods, sequenced with Illumina MiSeq, 454/Roche GSJunior, and Pacific Biosciences

5-virus-mix

SCICoNE

Single-cell copy number calling and event history reconstruction.

SCITE

Bayesian non-parametric clustering (BnpC) of binary data with missing values and uneven error rates

BnpC

Computes a consensus sequence with wobbles, ambiguous bases, and in-frame insertions, from a NGS read alignment.

ConsensusFixer

Java

scDEF

Deep exponential families for single-cell data.

Probabilistic inference of viral quasispecies subject to recombination (viral haplotype reconstruction).

QuasiRecomb

Java

pancancer-clustering

Bayesian network modelling of mutational interactions identifies novel cancer subgroups

netics

NetICS: network-based integration of multi-omics data for prioritizing cancer genes

MATLAB

cojac

VILOCA: VIral LOcal haplotype reconstruction and mutation CAlling for short and long read data

VILOCA

Map single-cell transcriptomes to copy number evolutionary trees.

SCATrEx

Finding the causality in biological pathways

dce

COMPASS

smallgenomeutilities is a collection of Python scripts to convert alignments between different reference genomes.

smallgenomeutilities

Inference in Bayesian Networks with R

SGS

pybda

💻💻💻 A commandline tool for analysis of big biological data sets for distributed HPC clusters.

ngshmmalign is a profile HMM aligner for NGS reads designed particularly for small genomes (such as those of RNA viruses like HIV-1 and HCV) that experience substantial biological insertions and deletions

ngshmmalign

Procedure used fro the surveillance of SARS-CoV-2 genomic variants in wastewater.

cowwid

scIsoPrep

Single-cell Iso Prep

BSSE COVID-19 sequencing of test swab samples

predictability_of_cancer_evolution

WES_Cancer_Sim

pangolin

Shell

pareg

Pathway enrichment computations using a regularized regression approach to incorporate inter-pathway relations in the statistical model.

infSCITE

Joint inference of exclusivity patterns and recurrent trajectories from tumor mutation trees

TreeMHN

scSomMerClock

Test for a molecular clock based on the phylogenetic tree inferred from single-cell DNA sequenzing data

Iterative and very sensitive Next-Generation Sequencing (NGS) sequence alignment software. Accounting for large deletions and removes indels, causing frame shifts. In addition, only specific regions can be considered.

InDelFixer

Java

PrimerID

Here we analyse the PrimerID protocol in all its gory details.

SCIPhIN

This is a adaptation to MHN so that it works on metastasis

metMHN

Network-Based Clustering of Pan-Cancer Data Accounting for Clinical Covariates

clustNet

Network-based clustering

graphClust_NeurIPS

slidr

An R package for identification of synthetic lethal partners for mutations from large perturbation screens.

PredictHaplo

This software aims at reconstructing haplotypes from next-generation sequencing data.

Inference and analysis of mutation trees in Python

PYggdrasil

MC-CBN performs large-scale inference on conjunctive Bayesian networks

MC-CBN

LolliPop

Deconvolution for Wastewater Genomics

Tree inference from mitochondrial mutations

mt-SCITE

Bioconductor package for finding mutually exclusive groups of alterations in large cancer datasets

TiMEx

mnem

Mixture Nested Effects Models - https://doi.org/10.1093/bioinformatics/bty602 - https://bioconductor.org/packages/mnem

SynNet

Toolbox for design and optimization of miRNA-based synthetic classifier pathways

MATLAB

gespeR

Gene-Specific Phenotype EstimatoR

timeseriesNEM

HDL-X

pMHN

Personalised mutual hazard networks

Inverse reinforcement learning for mutation trees

netprioR

PhIRL

A Snakemake workflow for large-scale SARS-CoV-2 analyses.

SARS-CoV-2_Analysis

Deep hierarchical models combined with Markov random fields.

oncotree2vec

JavaScript

cancer-type-prediction-from-tumour-DNA

shm

GeneAccord: An R package to detect patterns of mutual exclusivity and co-occurrence on the clone level in a cohort of cancer patients

GeneAccord

openproblems2021

Analysis of high-throughput genetic perturbation screens in R.

perturbatr

Jnotype

Exploratory analysis of binary data in JAX

wastewater-sample-processing-VILOCA

bnclustOmics

SARS-CoV-2-wastewater-sample-processing-VILOCA

QuasiFit is a Bayesian MCMC sampler for inferring fitness landscapes in the quasispecies model subject to mutation-selection equilibrium.

QuasiFit

Computes higher-order interactions such as 2-way, 3-way,…, n-way interaction coordinates and some circuits in the n-locus case taking as input 2^n experimental measurements.

ObservationMHN

epistasis-formulas

Nested Effects Models based Perturbation Inference - https://doi.org/10.1093/bioinformatics/btab113 - https://bioconductor.org/packages/nempi

nempi

myeloid-clustering

This repository contains supplementary information, data and code for the manuscript: Bayer et al. 2023, "Network-based clustering unveils interconnected landscapes of genomic and clinical features across myeloid malignancies"

fairClust

DBNclass

pcNEM

pathTiMEx

pathTiMEx is a model for the joint inference of mutually exclusive pathways and the dependencies among them in carcinogenesis

demoTape

Computational demultiplexing of targeted single-cell sequencing (tapestri) data

TMixClust

tree-embeddings