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Open-Systems-Pharmacology

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Documentation files for the Open Systems Pharmacology Suite

Suite

Open Systems Pharmacology Suite Setup

Rich Text Format

PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling

Forum

Discussion forum for the Open Systems Pharmacology Project

OSPSuite-R

R package for the OSPSuite

MoBi

MoBi® is a software tool for multiscale physiological modeling and simulation

Glucose-Insulin-Model

The physiologically-based whole-body model of the glucose-insulin-glucagon regulatory system

MATLAB

OSP-based-publications-and-content

Publications of all kind based on the Open Systems Pharmacology Suite

OSP-PBPK-Model-Library

Library of released PBPK substance models and evaluation reports

MATLAB

TLF-Library

TLF Library implementation in R

docs

Open Systems Pharmacology - Live Documentation

HTML

Pregnancy-Models

Physiologically Based Pharmacokinetic Models for Pregnant Women

OSPSuite.ReportingEngine

R implementation of the reporting engine

Digoxin-Model

Whole-body PBPK model of digoxin as P-gp DDI victim drug

OSPSuite.Core

Core functionalities of the Open Systems Pharmacology Suite

Inhalation-model

Implementation of inhalation model in MoBi

Skin-permeation-model

Implementation of Dancik et al (2013) skin permeation model in MoBi

OSPSuite.SimModel

Calculation engine for models built with PK-Sim® or MoBi®

C++

R-Toolbox

Vancomycin-Model

Whole-body PBPK model of Vancomycin

MATLAB

ISSX-2017-Cologne

Training materials for the OSP workshop at ISSX 2017, Cologne

BERLIN-2019-WORKSHOP

[FULLY BOOKED] SGS Exprimo and the FU Berlin will run a two-days hands-on PK-Sim® & MoBi® workshop on introducing PBPK for human dose projection and drug-drug interaction (DDI) prediction on 21st-22nd Feb 2019 at the Institute of Pharmacy, FU-Berlin, Germany.

OSPSuite.ParameterIdentification

R package for parameter identification for OSPS models

Matlab-Toolbox

Collection of Matlab® functions for the processing of PK-Sim® or MoBi® models

Rich Text Format

Vision-Mission

Vision & Mission of Open Systems Pharmacology

PAGE2017-Budapest

Training materials for the OSP workshop at PAGE 2017 Budapest

OSP-Qualification-Reports

Qualification Reports recreated with every new OSP Release

FDA-OSP-workshop-April-2021

OSPSuite.DataBinding

DataBinding framework for WinForms application used in the Open Systems Pharmacology Suite

OSPSuite.Plots

Figures and dependent tables which are used by R packages in the Open Systems Pharmacology ecosystem

ACoP-2018-Workshop

PK-Sim® & MoBi® (OSPS®) workshop on integrating PBPK with QSP

Thyroid-Hormones-PB-QSP-Model

Physiology-based systems pharmacology model of thyroid hormones regulation in rat and human

DCI

Data Component Interface used in the Open-Systems-Pharmacology Suite

C++

AGePOP-OSP-Workshop-2021

PAGE-2019-PBPK-Workshop

PK-Sim® & MoBi® (OSP Suite) workshop on PBPK

BOSTON-2018-Workshop

PK-Sim® & MoBi® workshop on integrating PBPK with QSP

Lung-absorption-model

Pulmonary drug absorption implemented in MoBi (Eriksson et al. 2020)

Clarithromycin-Midazolam-DDI

Modeling of published clinical Clarithromycin-Midazolam-DDI studies for model evaluation

InstallationValidator

Installation Validation Tool for the Open Systems Pharmacology Suite

Metoprolol-Model

PBPK model of metoprolol and metoprolol-CYP2D6 drug-gene interactions

PharMetrX-Workshop-March-2018

Training materials for the PharMetrX POSP PBPK workshop, Potsdam March 2018

Reporting-Engine

(Matlab) Reporting-Engine

MATLAB

Theophylline-Model

Whole-body PBPK model of theophylline as CYP1A2 DDI victim drug

Quinidine-DDGI-Model

Pediatric_Qualification_Package_CYP2C8_Ontogeny

Pediatric Qualification Package for CYP2C8 Ontogeny

MATLAB

OSPSuite.DataBinding.DevExpress

DataBinding Framework for DevExpress components used by the Open Systems Pharmacology Suite

Erythromycin-Felodipine-DDI

Carbamazepine-Alprazolam-DDI

Modeling of published clinical Carbamazepine-Alprazolam-DDI studies for model evaluation

Ritonavir-Model

PBPK model for ritonavir

Clarithromycin-Sildenafil-DDI

Itraconazole-Felodipine-DDI

Carbamazepine-Midazolam-DDI

Modeling of published clinical Carbamazepine-Midazolam-DDI studies for model evaluation

Carbamazepine-Efavirenz-DDI

Modeling of published clinical Carbamazepine-Efavirenz DDI studies for model evaluation

Erythromycin-Sildenafil-DDI

Itraconazole-Sildenafil-DDI

Erythromycin-Carbamazepine-DDI

Modeling of published clinical Erythromycin-Carbamazepine DDI studies for model evaluation

ACoP-2017-FortLauderdale

Training materials for the OSP workshop at ACoP 2017, Fort Lauderdale

Levonorgestrel

Whole-body PBPK model of levonorgestrel with and without ethinyl estradiol as CYP3A4 DDI victim drug

Voriconazole-Model

Whole-body PBPK model of voriconazole as CYP2C19 substrate and CYP3A4 perpetrator drug

Quinidine-Model

BE-Studies

ASCPT-Satelite-OSPS-Workshops

ASCPT2020 satellite workshops: PK-Sim® & MoBi® hands-on training for PBPK and PBPK-based QSP at University of Houston, College of Pharmacy (www.esqlabs.com/news-events)

Gene-Expression-Databases

Cimetidine-Alfentanil-DDI

Modeling of published clinical Cimetidine-Alfentanil-DDI studies for model evaluation

Cimetidine-Verapamil-DDI

Modeling of published clinical Cimetidine-Verapamil-DDI studies for model evaluation

Itraconazole-Model

Whole-body PBPK model of itraconazole as CYP3A4 and P-gp DDI perpetrator drug

MATLAB

Cimetidine-Midazolam-DDI

Modeling of published clinical Cimetidine-Midazolam-DDI studies for model evaluation

Cimetidine-Alprazolam-DDI

Modeling of published clinical Cimetidine-Alprazolam-DDI studies for model evaluation

Cimetidine-Carbamazepine-DDI

Modeling of published clinical Cimetidine-Carbamazepine DDI studies for model evaluation

Cimetidine-Model

Whole-body PBPK model of cimetidine (OCT2/MATE and CYP3A4 DDI perpetrator drug)

MATLAB

Cimetidine-Triazolam-DDI

Modeling of published clinical Cimetidine-Triazolam-DDI studies for model evaluation

OSPSuite.RUtils

Utility functions for Open Systems Pharmacology R packages

Open-Systems-Pharmacology/OSPSuite.Documentation

Open-Systems-Pharmacology

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