Discover Merck/curation-open-source Open Source project

BGC Detection and Classification Using Deep Learning

136

deepbgc

Halyard is an extremely horizontally scalable Triplestore with support for Named Graphs, designed for integration of extremely large Semantic Data Models, and for storage and SPARQL 1.1 querying of the whole Linked Data universe snapshots.

122

Halyard

Easily Create Production-Ready Rich Text Format (RTF) Table and Figure

106

r2rtf

DeepNeuralNet-QSAR

Matcher is a tool for understanding how chemical structure optimization problems have been solved. Matcher enables deep control over searching structure/activity relationships (SAR) derived from large datasets, and takes the form of an accessible web application with simple deployment. Matcher is built around the mmpdb platform.

matcher

RDF2X converts big RDF datasets to the relational database model, CSV, JSON and ElasticSearch.

rdf2x

Sapiens is a human antibody language model based on BERT.

Sapiens

Compact Package Representations

pkglite

sonar-r-plugin

Adds support for R language into SonarQube. It uses output from lintr tool which is processed by the plugin and uploaded into SonarQube server.

This is the Line of Therapy Algorithm, as described in the paper "Temporal phenotyping by mining healthcare data to derive lines of therapy for cancer" pending submission in the Journal of Biomedical Informatics.

Line-of-Therapy-Algorithm

Group Sequential Design Under Non-Proportional Hazards

gsDesign2

AlgebraicAgents.jl

A lightweight framework to enable hierarchical, heterogeneous dynamical systems co-integration. Batteries included!

Clinical trial simulation for time-to-event endpoints

simtrial

metalite.ae

An R package for standard adverse events analysis

BioPhi-2021-publication

This repository contains scripts, data and jupyter notebooks used to produce the evaluation results in the BioPhi 2021 publication

An R package to create metadata structure for ADaM data analysis and reporting

metalite

PepSeA

Application for mutagenic primer design. Facilitates development of biocatalysts (Green Chemistry) and new therapeutic proteins.

Mutation_Maker

A Julia package that implements a category of reaction (transportation) network-type dynamical systems.

ReactiveDynamics.jl

Interactive box plot for clinical trial analysis

boxly

mRNAid

Interactive forest plot for adverse events analysis

forestly

pmpo

Probabilistic Multi-Parameter Optimization (pMPO)

bgc-pipeline

Antibody Langauge Ensemble Fusion - fuses antibody structural ensemble and language representation for property prediction

AbLEF

Lightweight graph-based multiple comparison procedures

gMCPLite

GeneratedExpressions.jl

A Julia package that implements a metalanguage to support expression comprehensions.

Data-Profiler

A Shiny app for graphical multiplicity control

gMCPShiny

NNGP

Nearest Neighbor Gaussian Process

CEEDesigns.jl

A decision-making framework for the cost-efficient design of experiments, balancing the value of acquired experimental evidence and incurred costs.

Residence Time Distribution modeling in Python.

rtdpy

matcher-mmpdb

fuses molecular language and graph representation for property prediction

MolPROP

Real-world Time to Treatment Discontinuation Prediction Algorithm

Real-world-Time-to-Treatment-Discontinuation-Prediction-Algorithm

Perl

compoundcomplexity

This is an implementation of Compound Complexity for use in the SMART-PMI as described by Sherer et al. It contains derived training data as required by the described Random Forest Model in order to replicate data presented in paper as well as applying to novel data.

Perl

TraceTrack

The goal of gsdmvn is to enable group sequential trial design for time-to-event endpoints under non-proportional hazards assumptions.

gsdmvn

Message-Hub

The Messaging Orchestration HUB will be responsible for providing a connection between an organization's GS1 EPCIS-based track and trace data source system (for example ATTP) and the blockchain networks that require data relevant to product serialization and track & trace.

TypeScript

helm-visualisation

JavaScript

OMOP-CONCEPT-EMBEDDING

POLO: web interface to MARCO-scored crystallization images

polo

This library is made to perform feature selection based on a method originally proposed in by Sun et al. [1]. This library specifically relates to the methodology described in [2], named DEKER for decomposed kernel regression, which includes methods for identifying optimal hyperparameter values. This library was also designed for use in the context of network inference, also described in [2], by iteratively reapplying the DEKER method for feature selection across all features of a dataset.

deker

C++

BART-QSAR

3D_Tumor_Lightsheet_Analysis_Pipeline

The goal of bayesiansprt (under GPL-3 license) is to provide the results for sequential probability ratio test under frequentist and Bayesian setup.

MicroMap_Pipeline

ProbeDesign

HTML

bayesiansprt

mmrm

rCPDMS

Chemoproteomics Data Analysis

Infant-Microbiome-Cohort

Infant Microbiome Cohort