CardiacModelling/fitting-notebooks CardiacModelling/fitting-notebooks

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CardiacModelling/fitting-notebooks
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CardiacModelling

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Repository Details

Examples of parameter estimation in cardiac cell electrophysiology using Myokit and PINTS.

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1

markov-builder

Tool for building and manipulating Markov models of ion-channel kinetics
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2

FourWaysOfFitting

Code to compare four different ways to fit an ion current model
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3

RapidCharacterisationProtocols

Collection of experimental protocols in common patch clamp formats for rapid characterisation of ion channels
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4

fickleheart-method-tutorials

Code for the tutorials in the Fickle Heart model calibration with discrepancy 2020 paper.
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5

VoltageClampModel

Code to add a mathematical model of voltage-clamp artefacts to your ion channel simulations
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6

hERGRapidCharacterisation

Rapid characterisation of hERG channel kinetics
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7

BenNevis

"Where is Ben Nevis" presents the landscape of Great Britain as a testbed for optimisation and sampling methods.
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8

ap-nimbus-client

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9

hERG-binding-mechanisms

Source code and data for reproducing "The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk".
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10

WIRES

Figures and code for examples in WIREs review on calibrating electrophysiology models
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11

ionBench

A benchmarking tool for comparing different parameter optimization algorithms for ion channel models
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12

space-filling-designs

Phase-voltage space filling optimal designs in Matlab
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13

ical-model-review

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14

ap-nimbus

Cardiac modelling in containers
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15

ap-nimbus-app-manager

API for cloudified AP Predict
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16

appredict-docker

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17

Gamma_0

Code associated with a publication on the action potential model parameter representing missing charge
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18

nonlinear-time-dependent-leak

Data and code for reproducing the results in the nonlinear time-dependent leak paper.
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19

pcpostprocess

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20

syncropatch_export

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21

tailored-ipsc-models

Code to reproduce the simulations and figures in "Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology"
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22

L-type-Ca-rundown-experiments

An investigation of rundown in automated patch clamp L-type calcium current
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